Trauma fixation orthopaedic implants, such as titanium and stainless steel, though successful, can lead to complications1, 2, 3 requiring secondary procedures to remove.
Degradable polymers resorb over time, negating the need for removal. However, their low strength limits their applications and they can have issues such as foreign body reactions4.
Concerns with permanent cardiovascular stents include risk of thrombosis, neointimal tissue growth, and vessel caging causing abnormal vasomotion5
Magnesium alloys offer the potential to combine the mechanical property benefits of metallic implants with the bioabsorbable nature of degradable polymers
Magnesium resorbs without acidic degradation products and can be seen during radiography6.
Magnesium is also an essential mineral in the body – approximately 24g is naturally present in adults7
- Wong L, Dufresne CR, Richtsmeier JT, Manson PN. The effect of rigid fixation on growth of the neurocranium. Plast Reconstr Surg. 1991 Sep;88(3):395–403.
- Alpert B, Seligson D. Removal of asymptomatic bone plates used for orthognathic surgery and facial fractures. J Oral Maxillofac Surg. 1996 May;54(5):618–21.
- Taylor M, Tanner KE. Fatigue failure of cancellous bone: a possible cause of implant migration and loosening. J Bone Joint Surg Br. 1997 Mar;79(2):181–2
- Mauli Agawal C – Polymer Based Systems on Tissue Engineering, Replacement and Regeneration, Springer Netherlands, 2002, pp 25-36
- Jens Wiebe, MD; Holger M. Nef, MD; Christian W. Hamm, MD. Current Status of Bioresorbable Scaffolds in the Treatment of Coronary Artery Disease. J Am Coll Cardiol. 2014;64(23):2541-2551. doi:10.1016/j.jacc.2014.09.041
- Biber R. Magnesium-Based Absorbable Metal Screws for Intra-Articular Fracture Fixation, Case Rep Orthop. 2016
- Jeroen H. F. Magnesium in Man: Implications for Health and Disease, Physiological Reviews Published 1 January 2015 95 no. 1, 1-46